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Image Search Results
Journal: Human Gene Therapy
Article Title: Adeno-Associated Virus Serotype-9 Microdystrophin Gene Therapy Ameliorates Electrocardiographic Abnormalities in mdx Mice
doi: 10.1089/hum.2008.058
Figure Lengend Snippet: Neonatal AAV-9 microdystrophin therapy improves the ECG profile in young adult mdx mice. (A) Representative serial lead II tracings from mdx, AAV microgene-treated mdx, and BL10 mice. RR, the time interval between two QRS complexes. It is inversely correlated with the heart rate. The dotted lines denote the relative position of an RR interval in BL10 mice. (B) Representative single lead II tracing from mdx, AAV microgene-treated mdx, and BL10 mice. PR, the time interval between the onset of atrial depolarization and the onset of ventricular depolarization. QT, time interval between the onset of ventricular depolarization and the end of ventricular repolarization. The dotted lines denote the approximate positions of the PR and QT intervals. (C) ECG profiles from mdx, AAV microgene-treated mdx, and BL10 mice. *Significantly different from that of mdx (p < 0.04); **significantly different from that of mdx (p ≤ 0.001). Significant differences between BL10 and AAV-treated mdx are marked for HR, PR, QTc, and cardiomyopathy index. The QRS duration and the Q amplitude showed no significant difference among BL10, mdx, and AAV-treated mdx mice. HR, heart rate; PR, PR interval; QRS, QRS duration; QTc, heart rate-corrected QT interval; Q Amp, Q amplitude in lead I; C. Index, cardiomyopathy index.
Article Snippet: Beats from a continuous 1-min recording were averaged to generate a signal-averaged ECG for analysis with
Techniques: